At least 21 civilians including five children were killed Monday in airstrikes targeting ISIS's Syrian de facto capital of Raqqa, activists said.
The Syrian Observatory for Human Rights was not able to determine who carried out the raids, but the city has been targeted regularly by aircraft of the U.S.-led coalition and sometimes by government warplanes.
"The death toll could increase as some people are gravely wounded and others have gone missing," said the Britain-based group, which relies on a large network of opposition-aligned activists inside Syria for its information.
A U.S.-backed Arab-Kurdish alliance last month launched an assault to retake Raqqa city from the extremist group.
In the central province of Hama, meanwhile, at least 53 civilians including 16 children were killed earlier on Monday in airstrikes targeting areas also under ISIS control.
Monday's raids come a day after ISIS recaptured all of the desert city of Palmyra, sparking new concerns about the remaining ancient treasures at the UNESCO World Heritage site.
The Syrian army backed by airstrikes from government ally Russia had expelled the extremists from Palmyra in March, after ISIS first seized the city in May 2015.
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