The strikes hit al-Zyanat village near Markada town, ISIS last stronghold in Hasaka.
Last Wednesday, U.S. strikes killed 12 members in Tel al-Shayer area in the southern countryside of Hasaka.
The death toll from the Coalition strikes reach a total of 500 people in the past three months, according to local monitoring groups. Most victims were family members.
The US-led air campaign against the Islamic State jihadist group in Syria began on September 23, 2014.
The aerial bombing pushed thousands of people to flee ISIS-held areas in northeastern Syria. 100 displaced people from Deir Ezzor province arrived to Qana camp in Hasaka last Saturday.
Qana camp, which is a shelter for displaced people of eastern countryside of Deir Ezzor, is suffering from lack of aid and healthcare that left three children dead, according to the reporter.
Meanwhile, U.S.-backed Syrian Democratic forces militias have captured a town south of the city of Raqqa where ISIS ran a major military base and training camp, Reuters said on Tuesday.
SDF media official Mustafa Bali said the militias had seized the town of al-Ukeirshi, some 15 km (10 miles) downstream from Raqqa on the Euphrates river.
The SDF pushed into Raqqa last month after a long offensive, backed up by airstrikes and special forces from the U.S.-led coalition.
Syria's conflict evolved from a bloody crackdown on protests in 2011 into to a devastating war that has drawn in world powers, including Russia and a US-led international coalition.
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