Israeli military and police forces were on the search for pieces of a Syrian anti-aircraft missile that landed in southern Israel early Thursday.
The missile set off air raid sirens near the country's top-secret nuclear reactor in Dimona, the Israeli military said.
In response, it said it attacked the missile launcher and air-defence systems in neighbouring Syria.
Parts of the missile were found in Ashalim, a kibbutz (communal settlement) in southern Israel, approximately 20 miles (32 kilometres) southwest of Dimona, as well as in a nearby power plant.
Experts were seen on Thursday entering the power plant compound in the area to retrieve missile debris.
Israeli media later described the Syrian missile as an "errant" projectile, not a deliberate attack deep inside Israel.
In recent years, Israel has repeatedly launched air strikes at Syria, including at military targets linked to foes Iran and the Lebanese Hezbollah militia, both allies of Syrian President Bashar Assad.
Such strikes routinely draw Syrian anti-aircraft fire.
Thursday's exchange was unusual because the Syrian projectile landed deep inside Israel.
Syria's state news agency SANA said the exchange began with an Israeli air strike on Dumeir, a suburb of the capital of Damascus.
Dumeir is believed to house Syrian army installations and batteries as well as bases and weapons depots belonging to Iran-backed militias.
SANA said four soldiers were wounded.
The Israeli military described the projectile that landed near the nuclear site as a surface-to-air missile, which is usually used for air defence against warplanes or other missiles.
That could suggest the Syrian missile had targeted Israeli warplanes but missed and flew off errantly.
However, Dimona, the Negev desert town where Israel's nuclear reactor is located, is some 300 kilometres (185 miles) south of Damascus, a long range for an errantly fired surface-to-air missile.
The Israeli army said it had deployed a missile defence system but could not confirm if the incoming missile was intercepted, though it said there had been no damage.
The air raid sirens were sounded in Abu Krinat, a village just a few kilometres (miles) from Dimona.
Explosions heard across Israel might have been the air-defence systems.
The military said that in response to the incoming missile, it launched an air strike at the battery that launched the anti-aircraft missile and other surface-to-air batteries in Syria.
The exchange between Israel and Syria comes against the backdrop of growing tensions between Israel and Iran, a key ally of Syria.
Iran, which maintains troops and proxies in Syria, has accused Israel of a series of attacks on its nuclear facilities, including sabotage at its Natanz nuclear facility on April 11, and vowed revenge.
It also threatened to complicate U.S.-led attempts to revive the international nuclear deal with Iran.
AP
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