Medecins Sans Frontieres says hospitals it supports in Syria treated about 3,600 patients with "neurotoxic symptoms", of whom 355 have died.
It said the patients had arrived in three hospitals in the Damascus governorate on 21 August - when opposition activists say chemical attacks were launched against rebels, according to BBC.
It appears to provide more evidence of chemical weapons use.
Western countries have accused the government. Damascus accuses rebels.
MSF says staff at the hospitals described a large number of patients arriving with symptoms including convulsions, extreme salivation, contracted pupils and sight and respiratory problems, BBC reported.
The charity said many were treated with atropine, a drug administered to those with "neurotoxic symptoms".
MSF says that while it cannot scientifically confirm the cause of the symptoms, they "strongly suggest" the use of a nerve agent.
The Death tools reach 1821 people, mostly women and children.
More than 200,000 people have been killed in the Syrian conflict, according to Syrian Human rights NGO's and 1.7 million Syrians, including one million children, have been forced to flee to neighboring countries, the United Nations says.
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